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Theoretically, this effect would reduce GABA's inhibitory influence and thus potentially contribute to the excessive emotions and behaviors seen in AAS abuse. Various studies have linked increased anxiety and aggression, and both increased and decreased libido to AAS use. Effects on Relative Levels of GABA Receptor mRNA: The researchers measured the effects induced by anabolic androgenic steroids (AAS) on GABAa receptor subunit mRNA levels for male and female mice treated with 17α-MeT for 3 (blue) or 6 (purple) weeks. Six weeks of AAs exposure decreased the amount of one of the α subunits of the receptor apha2 only in female mice. No significant effects were observed in the treated male mice.


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